THE WALL STREET JOURNAL | BUSINESS
7th Apr.2011 By JENNIFER CORBETT DOOREN
Strawberries have the potential to prevent esophageal cancer, according to a preliminary study released
Wednesday.
Researchers, led by Ohio State University, were able to show that freeze-dried strawberries slowed the growth of
dysplastic, or precancerous, lesions in about 30 people who consumed the fruit for six months.
The study's lead researcher, Tong Chen, an assistant professor in the oncology division of Ohio State University,
presented the study at the American Association for Cancer Research's annual meeting.
Strawberries have the potential to prevent esophageal cancer, according to a preliminary study released Wednesday.
Esophageal cancer is the third most common gastrointestinal cancer and the sixth most frequent cause of cancer
death in the world, Dr. Chen said. About 16,000 new cases of esophageal cancer a year are diagnosed in the
U.S., according to the American Cancer Society.
Dr. Chen and a group of researchers are studying esophageal squamous cell carcinoma, the dominant type of
esophageal cancer world-wide. They are looking at whether food or other substances might prevent cancer.
Previous work showed that freeze-dried strawberries were able to significantly inhibit tumor development in rats.
The research team designed a small study in humans and approached the California Strawberry Commission,
which agreed to fund the study and make available the freeze-dried strawberries. The commission is a state
agency funded by the strawberry industry.
Dr. Chen's team recruited 38 people in China who had mild-to-moderate dysplasia in the esophagus; 36 people
completed the study. Biopsies of the esophagus were taken before and after the study. On average, patients were
about 55 years old.
They were instructed to consume 30 grams of freeze-dried strawberries dissolved in a glass of water twice daily
for a total of 60 grams a day for six months. Dr. Chen said the freeze-dried substance is about 10 times as
concentrated as fresh strawberries, but suggested people could still benefit from eating whole strawberries on a
daily basis.
Overall, the results showed 29 out of 36 participants experienced a decrease in histological grade of the
precancerous lesion, or a slowing in the growth of the lesion during the study. Dr. Chen said larger, randomized
placebo-controlled studies are needed to confirm the results. She said it isn't clear exactly what the anti-cancer
agent in strawberries might be. But she noted that strawberries contain a variety of vitamins, minerals and other
substances known as phytochemicals, which are also found in some other types of berries.